Polydopamine coated manganese oxide nanoparticles with ultrahigh relaxivity as nanotheranostic agents for magnetic resonance imaging guided synergetic chemo-/photothermal therapy.
نویسندگان
چکیده
Mn-based nanoparticles have been regarded as a new class of probes for magnetic resonance imaging (MRI), but their low relaxivity is the major obstacle for applications in vivo. Herein, we designed and constructed a multifunctional nanotheranostic (FA-Mn3O4@PDA@PEG) for MRI guided combinatorial chemo-/photothermal therapy (PTT) for cancer. The ultrahigh relaxivity of 14.47 mM-1 s-1 makes the nanotheranostic an excellent contrast agent for MRI in vitro and in vivo, and provides comprehensive information for tumor diagnosis. When irradiated with an 808 nm NIR laser, FA-Mn3O4@PDA@PEG exhibits a remarkably improved and synergistic therapeutic effect compared to PTT or chemotherapy alone, providing high therapeutic efficiency and low side effects of drugs. These findings are of great interest and will inspire us to develop highly effective MRI guided synergetic chemo-/photothermal therapy for cancer treatment.
منابع مشابه
Polydopamine coated manganese oxide nanoparticles with ultrahigh relaxivity as nanotheranostic agents for magnetic resonance imaging guided synergetic chemo-/photothermal therapy† †Electronic supplementary information (ESI) available: Experimental procedures, supplementary figures and table of relaxivity of the present work and reported Mn-based nanoparticles. See DOI: 10.1039/c6sc01320a Click here for additional data file.
State Key Laboratory of Rare Earth Reso Applied Chemistry, Chinese Academy of Sc E-mail: [email protected]; [email protected] State Key Laboratory of Inorganic Synthes Chemistry, Jilin University, Changchun 1300 Department of Radiology, The Second H 130022, P. R. China † Electronic supplementary information (E supplementary gures and table of relax Mn-based nanoparticles. See DOI: 10.1039 Cite th...
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ورودعنوان ژورنال:
- Chemical science
دوره 7 11 شماره
صفحات -
تاریخ انتشار 2016